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KMID : 0043320170400030311
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Archives of Pharmacal Research
2017 Volume.40 No. 3 p.311 ~ p.317
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A new saponin from Acanthopanax koreanum with anti-inflammatory activity
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Dat Le Duc
Thao Nguyen Phuong
Luyen Bui Thi Thuy
Tai Bui Huu
Woo Mi-Hee
Manzoor Zahid
Ali Irshad
Koh Young-Sang
Kim Young-Ho
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Abstract
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Twelve saponins were isolated from the leaves of Acanthopanax koreanum, including one new lupane-type triterpene glycoside, named acankoreoside R (1), together with 11 known triterpenoid saponins (2?12). Their structures were elucidated by 1D and 2D nuclear magnetic resonance (NMR), mass spectroscopic data (MS). All of the fractions and isolated saponins were evaluated for anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) by ELISA. Among them, compounds 1?5, 7, 10, and 12 showed strong inhibitions towards interleukin-12 (IL-12) production with IC50 values ranging from 1.59 to 5.46 μM. Other compounds were weak or inactive toward IL-12 p40 production.
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KEYWORD
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Acanthopanaxkoreanum, Lupane saponin, IL-12
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